The West Coast star passed away in Long Beach, California, in the early hours of yesterday morning, according to his family.
The cause of death remains unknown, though he did suffer a stroke in December 2007 that rendered the left side of his body paralysed.with Dre, Snoop and Kurupt; and 2003 tune 21 Questions, with 50 Cent.
In April 2002 he was arrested and charged with firearms and drugs offences in Arizona, pleading guilty at trial and sentenced to probation and community service.
He released three albums during his career - 1998's G-Funk Classics, Vol. 1 & 2, 2001's Music And Me, and an eponymously titled 2004 collection.
However, he'll be best remembered for his collaborations, having contributed to over 40 charted singles.
His distinctively deep voice also played a big role on Dre's top-selling 1991 album The Chronic.